Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.

doi:10.1016/j.bmcl.2008.06.064

Paper

Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.

Published Jul 15, 2008 · C. Park, So Young Kim, W. Park

Bioorganic & medicinal chemistry letters

Q2 SJR score

21

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Abstract

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Study Snapshot

The novel series of 1H-indole-3-carboxylic acid pyridine-3-ylamides show high affinity and selectivity for 5-HT2C receptor, with 15k showing the highest affinity and selectivity over other serotonin and dopamine receptors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.

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