Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids

doi:10.1016/0223-5234(94)90063-9

Paper

Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids

Published 1994 · G. Caliendo, G. Cirino, G. Greco

European Journal of Medicinal Chemistry

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7

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0

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Abstract

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In Vitro Study

Study Snapshot

Some 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids show analgesic-antiinflammatory activity similar to tolmetin, with electron-releasing substituents in the para-position of the benzoyl moiety promoting activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis and structure-activity relationships of antiinflammatory 1-methyl-2-(4-X-benzoyl)imidazole-5-acetic acids

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