Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.

doi:10.1016/j.bmc.2019.03.061

Paper

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.

Published May 15, 2019 · Patrick Hochegger, J. Faist, W. Seebacher

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

The 6-fluoro-2-4-[(4-methylpiperazin-1-yl)methyl]phenyl-N-[2-(pyrrolidin-1-yl)ethyl]quinoline-4-carboxamide] showed high antiplasmodial activity against Plasmodium

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.

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References

Citations

Pyridine and Pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development.

Pyridine and pyrimidine hybrids show promise in developing effective antimalarial agents and reducing drug resistance, offering a promising strategy for combating drug-resistant strains of malaria.

Design and synthesis of pyrano[2,3-c]pyrazole-4-aminoquinoline hybrids as effective antimalarial compounds.

Pyrano[2,3-c]pyrazole-4-aminoquinoline hybrids show potential as potent antimalarial agents, with nine showing superior activity against drug-resistant Plasmodium falciparum strains.

Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond.

Recent developments in 4-aminoquinoline-based molecular hybrids show promise for cost-effective, selective, safe, and more potent drug development in diverse biological activities.

2,4-disubstituted 6-fluoroquinolines as potent antiplasmodial agents: QSAR, homology modeling, molecular docking and ADMET studies

Novel 2,4-disubstituted 6-fluoroquinolines with high antiplasmodial activity and good structural properties show potential as effective inhibitors of a novel antimalarial drug target.

Recent developments in antimalarial activities of 4-aminoquinoline derivatives.

4-aminoquinoline derivatives hybridized with various heterocyclic scaffolds show promising antimalarial efficacy against diverse Plasmodium clones, aiding in the development of more effective antimalarial agents.