Paper

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.

Published May 15, 2019 · Patrick Hochegger, J. Faist, W. Seebacher

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

The 6-fluoro-2-4-[(4-methylpiperazin-1-yl)methyl]phenyl-N-[2-(pyrrolidin-1-yl)ethyl]quinoline-4-carboxamide] showed high antiplasmodial activity against Plasmodium

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.

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