Synthesis and DTF studies of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as an efficient key precursor

doi:10.24820/ARK.5550190.P011.415

Paper

Synthesis and DTF studies of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as an efficient key precursor

Published Feb 8, 2021 · Ahmed F. Darweesh, Nesma A. Abd El-Fatah, Samir A. Abdel-Latif

Arkivoc

Q4 SJR score

12

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0

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Abstract

Novel 9-aminoimidazo[1,2-a:5,4-b']dipyridine-6,8-dicarbonitriles were prepared via the Michael addition reaction of readily accessible 2-(3H-imidazo[4,5-b]pyrid-2-yl)acetonitrile with arylidenemalononitriles. The regioselectivity of the reaction was supported by theoretical calculations at the DFT level. In contrast, the reaction of the appropriate bis-arylidenemalononitrile with 2-(3H-imidazo[4,5-b]pyrid-2-yl)acetonitrile under similar reaction conditions gave the corresponding bis[2-(3H-imidazo[4,5-b]pyrid-2-yl)acrylonitriles].

Study Snapshot

This study demonstrates the efficient synthesis of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as a key precursor, with promising regioselectivity and theoretical calculations supporting the reaction's theoretical

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis and DTF studies of novel aminoimidazodipyridines using 2-(3H-imidazo[4,5-b]pyridin-2-yl)acetonitrile as an efficient key precursor

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References

The Catalytic, Enantioselective Michael Reaction

The catalytic enantioselective Michael reaction allows for efficient synthesis of substituted 1,5-dicarbonyl compounds with high enantio- and stereocontrol, using transition metal catalysis and organocatalysis methods.

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