Synthesis and study of antiinflammatory and analgesic activity of 1-hydrazino-3,3-dialkyl-3,4-dihydroisoquinoline derivatives

doi:10.1007/BF02471885

Paper

Synthesis and study of antiinflammatory and analgesic activity of 1-hydrazino-3,3-dialkyl-3,4-dihydroisoquinoline derivatives

Published May 1, 1998 · V. A. Glushkov, Y. Shklyaev, G. A. Tul'bovich

Pharmaceutical Chemistry Journal

1

Citations

0

Influential Citations

Full text

Abstract

As is known, the class of 3,4-dihydroisoquinoline derivafives exhibits a broad spectrum of pharmacological activity [1 -4] , including compounds producing spasmolytic [5], antiarrhythmie and antiaggregative [6], and hypotensive effects [7]. Acid hydrazides and hydrazones of earbonyl compounds constitute another class of substances offering a broad spectrum of biological activity. Therefore, it would be of interest to study the compounds whose molecules include pharmacophore groups belonging to beth classes. For this study we have selected a previously described compound, l-hydrazono-3,3-dimethyl1,2,3,4-tetrahydroiso quinoline (Ha) [8], and 1-hydrazono-3,3-tetramethylene-

Study Snapshot

1-hydrazino-3,3-dialkyl-3,4-dihydroisoquinoline derivatives show antiinflammatory and analgesic activity, with potential applications in treating various diseases.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and study of antiinflammatory and analgesic activity of 1-hydrazino-3,3-dialkyl-3,4-dihydroisoquinoline derivatives

References

Citations