Stereoselective synthesis of substituted 2,5-diazabicyclo[2.2.1]heptanes by iodine-mediated cyclization of optically pure compounds containing the 4,5-diamino-1,7-octadiene and 1,2-diamino-4-alkene moieties.

doi:10.1016/J.TET.2007.09.035

Paper

Stereoselective synthesis of substituted 2,5-diazabicyclo[2.2.1]heptanes by iodine-mediated cyclization of optically pure compounds containing the 4,5-diamino-1,7-octadiene and 1,2-diamino-4-alkene moieties.

Published Dec 10, 2007 · Giuseppe S. Alvaro, R. D. Fabio, A. Gualandi

Tetrahedron

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8

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2

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Abstract

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Study Snapshot

This study demonstrates a stereoselective synthesis of substituted 2,5-diazabicyclo[2.2.1]heptanes by iodine-mediated cyclization of optically pure compounds containing the 4,5-diamino-1,7-octadiene

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Stereoselective synthesis of substituted 2,5-diazabicyclo[2.2.1]heptanes by iodine-mediated cyclization of optically pure compounds containing the 4,5-diamino-1,7-octadiene and 1,2-diamino-4-alkene moieties.

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References

Citations

Crystal structure of (1S,4S)-2,5-diazoniabicyclo[2.2.1]heptane dibromide

The crystal structure of (1S,4S)-2,5-diazoniabicyclo[2.2.1]heptane dibromide reveals a complex three-dimensional network of N-HBr hydrogen bonds, maintaining charge balance and linking components.

Synthesis of Chiral Azabicycles from Pyroglutaminols.

This study demonstrates a stereocontrolled synthesis of chiral bicyclic morpholine and piperazine derivatives from substituted pyroglutaminols, offering new opportunities for drug discovery.

Octa‐1,7‐diene‐4,5‐diamine Derivatives: Useful Intermediates for the Stereoselective Synthesis of Nitrogen Heterocycles and Ligands for Asymmetric Catalysis

Octa-1,7-diene-4,5-diamine derivatives are useful intermediates for the stereoselective synthesis of nitrogen heterocycles and asymmetric catalysis.

Synthesis of (1R,4R)-2,5-diazabicyclo[2.2.1]heptane derivatives by an epimerization–lactamization cascade reaction

The developed epimerization-lactamization cascade reaction effectively synthesizes (1R,4R)-2,5-diazabicyclo[2.2.1]heptane derivatives, with electron-withdrawal N-protective groups and strong bases as key factors.

Recent developments in the synthesis of five- and six-membered heterocycles using molecular iodine.

Iodine-mediated synthesis of heterocyclic compounds has advanced since 2006, with a focus on ring formation mechanisms and functional group manipulation.