Paper

Synthesis of substituted 5-bromomethyl-4-nitroimidazoles and use for the preparation of the hypoxia-selective multikinase inhibitor SN29966

Published Oct 28, 2013 · Guo‐Liang Lu, Amir Ashoorzadeh, R. Anderson

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Abstract

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Study Snapshot

This study demonstrates an efficient two-step synthesis of 5-(bromomethyl)-1-methyl-4-nitro-1 H-imidazole, a key precursor for the preparation of hypoxia-selective pan-ErbB inhibitor SN29966, and its analogues.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis of substituted 5-bromomethyl-4-nitroimidazoles and use for the preparation of the hypoxia-selective multikinase inhibitor SN29966

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