Paper
Synthesis of some substituted 6,7-dihydro-4-methoxy-7-methyl-7-substituted-5-oxo-5H-furo[3,2-g]chromene-9-sulfonate derivatives as potent antihypertensive α-blocking and antiarrythmic agents
Published Sep 16, 2017 · A. Amr, M. Abdalla, S. A. Essaouy
Russian Journal of General Chemistry
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Abstract
A number of substituted 4-methoxy-7-methyl-6-(substituted methyl)-5-oxo-5H-furo[3,2-g]-chromene-9-sulfonates 3a–3f and 4a–4c were synthesized. Treatment of visnagin-9-sulphonyl esters by secondary amines gave the substituted 6,7-dihydro-4-methoxy-7-methyl-7-substituted-5-oxo-5H-furo[3,2-g]-chromene-9-sulfonates 5a–5f and 6a–6c. Some of synthesized compounds were tested as potential α-blocking and antiarrythmic agents.
Study Snapshot
Substituted 6,7-dihydro-4-methoxy-7-methyl-7-substituted-5-oxo-5H-furo[3,2-g]-chromene-9-sulfonate derivatives show potential as potent antihypertensive -block
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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