Paper

Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-НТ6 receptors.

Published Aug 1, 2013 · A. Ivachtchenko, E. Golovina, M. Kadieva

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Substituted diphenyl sulfones show strong antagonistic activities towards 5-HT6 receptors, with compounds 10g and 10m showing 150-fold increases in potency.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-НТ6 receptors.

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