Synthesis and Synthetic Applicationsof Samarium Enolates of Unmasked Amides: Efficient Synthesis of3-Aminoamides and 3-Amino-2-chloroamides

doi:10.1055/S-0030-1258535

Paper

Synthesis and Synthetic Applicationsof Samarium Enolates of Unmasked Amides: Efficient Synthesis of3-Aminoamides and 3-Amino-2-chloroamides

Published Sep 1, 2010 · J. Concellón, H. Rodríguez‐Solla, Carmen Concellón

Synlett

Q3 SJR score

7

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Unprotected samarium acetamide and chloroacetainide enolates were prepared by treatment of iodoacetamide and dichloroacetamide with SmI 2 . The addition of these samarium-based enolates to aldimines was efficiently performed affording 3-aminoamides and 3-amino-2-chloroamides in high yields. A mechanism is proposed to explain the synthesis and reactivity of samarium enolates of primary amides.

Study Snapshot

Samarium enolates of primary amides efficiently synthesize 3-aminoamides and 3-amino-2-chloroamides in high yields, with a proposed mechanism explaining their synthesis and reactivity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Synthesis and Synthetic Applicationsof Samarium Enolates of Unmasked Amides: Efficient Synthesis of3-Aminoamides and 3-Amino-2-chloroamides

Sign up to use Study Snapshot

References

Citations

Triflic Acid-Promoted 1,2-Amino Migration Reactions in α-Arylaminoacrylamides: Access to Substituted β-Aminoamides.

This study presents a one-pot two-step synthetic protocol for synthesizing substituted -aminoamides from -arylamino--hydroxyacrylamides and their tautomeric mixture, offering high chemoselectivity and operational simplicity.

The Fascinating Chemistry of α‐Haloamides

Haloamides offer a rich chemistry for discovering new bond forming reactions, enabling diverse cyclic compounds, and playing a crucial role in life and materials science.

Reaction mechanisms: radical and radical ion reactions

Recent developments in synthetic radical chemistry and understanding of radical reactions in biological systems are crucial for developing new synthetic procedures and understanding their effects on human health.

8.06 Reduction of C X to CH XH by Dissolving Metals and Related Methods

Reduction of C-X double bonds to CH-XH using dissolving metals is a versatile and effective method for organic synthesis, offering complementary stereochemistry and a versatile approach for complex molecular frameworks.