1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline is an important intermediate for organic synthesis. A novel process was developed for the synthesis of the title compound in an overall yield of 53% from phenethylamine. Improvements were achieved by using mixture of P2O5/ POCl3 instead of P2O5 as the dehydrating agent,less methanol, more tetrahydropyrrole and recrystallization in place of column chromatography for the purification.

The novel process improves the synthesis of 1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride with a 53% yield from phenethylamine by using P2O5/POCl3 as a

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Improvement on the Synthesis of 1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline Hydrochloride

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