Improvement on the Synthesis of 1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline Hydrochloride

Paper

Improvement on the Synthesis of 1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline Hydrochloride

Published 2013 · Feng Ta

Fine Chemical Intermediates

UNKNOWN SJR score

0

Citations

0

Influential Citations

Semantic Scholar

Abstract

1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline is an important intermediate for organic synthesis. A novel process was developed for the synthesis of the title compound in an overall yield of 53% from phenethylamine. Improvements were achieved by using mixture of P2O5/ POCl3 instead of P2O5 as the dehydrating agent,less methanol, more tetrahydropyrrole and recrystallization in place of column chromatography for the purification.

Study Snapshot

The novel process improves the synthesis of 1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride with a 53% yield from phenethylamine by using P2O5/POCl3 as a

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Improvement on the Synthesis of 1-(Pyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline Hydrochloride

Sign up to use Study Snapshot

References

Citations