Synthesis of tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate

doi:10.2991/IWMECS-15.2015.46

Paper

Synthesis of tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate

Published Oct 25, 2015 · Min Wang, Wenhui Wang, Qidong Tang

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Abstract

Tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate (1) is the key intermediate of Vandetanib. It was synthesized from piperidin-4-ylmethanol (2) through three steps Including acylation, sulfonation and substitution. The structures and the synthetic route were determined by MS and 1HNMR.And the synthetic method was optimized. The total yield of the three steps was 20.2%.

Study Snapshot

The key intermediate for Vandetanib, tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate, was synthesized with a 20.2% yield from piperidin-4-yl

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Synthesis of tert-butyl 4-((2-methoxy-4-(methoxycarbonyl) phenoxy) methyl) piperidine-1-carboxylate

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