[Synthesis of thieno[2,3-d]pyrimidine derivatives and their antifungal activities].

doi:10.1248/YAKUSHI1947.109.7_464

Paper

[Synthesis of thieno[2,3-d]pyrimidine derivatives and their antifungal activities].

Published Jul 25, 1989 · S. Konno, M. Tsunoda, R. Watanabe

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

UNKNOWN SJR score

8

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0

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Abstract

4-Chlorothieno[2,3-d]pyrimidines were prepared by the chlorination of 4-oxo-3,4-dihydrothieno[2,3-d]pyrimidines with phosphoryl chloride. 4-Oxo-3,4,5,6,7,8-hexahydro[1]-benzo- and 4-oxo-6-phenylthieno[2,3-d]pyrimidine were synthesized by the cyclization of 2-acylaminothiophene-3-carboxamide derivatives with base. 2-Methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine was prepared by the treatment of 2-methyl-4-trichloromethylthieno-[2,3-d]pyrimidine with sodium hydroxide in aqueous methanol. A series of 4-alkylamino- and 4-arylaminothieno[2,3-d]pyrimidines were synthesized by the nucleophilic substitution of 4-chlorothieno[2,3-d]pyrimidines with various amines. These compounds were evaluated for antifungal activity against Piricularia oryzae. The preventive effects on Rice blast, Sheath blight, and Cucumber powdery mildew were also determined by pot tests.

Study Snapshot

Thieno[2,3-d]pyrimidine derivatives show antifungal activity against Piricularia oryzae and potential preventive effects against Rice blast, Sheath blight, and Cucumber powdery mildew.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

[Synthesis of thieno[2,3-d]pyrimidine derivatives and their antifungal activities].

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References

Citations

Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure–Activity Relationship

Thienopyrimidine derivatives show functional efficacy and selectivity as GPR55 antagonists, potentially benefiting various diseases.

Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm.

Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid accumulation, while preserving kinase inhibitory activity, offering potential for chemical probes in lipid metabolism studies.

Studies on the reaction of N‐(3‐carbethoxy‐4,5,6,7‐tetrahydrobenzo[b]thien‐2‐yl)‐N′‐phenylthiourea with hydrazine hydrate (Part 1)

This study demonstrates the potential of N-(3-carbethoxy-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-N′-phenylthiourea with hydrazine hydrate for the synthesis of tetracyclic compounds

Synthesis and antimicrobial activity of novel tetrahydrobenzothienopyrimidines

Novel tetrahydrobenzothienopyrimidines show promising antimicrobial activity against various bacteria, with compound 15e showing the broadest spectrum of activity.

Synthesis, Chemistry, and Biological Properties of Thienopyrimidines

Thienopyrimidines have diverse chemistry and biological properties, with various syntheses and applications.