Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives.

doi:10.1016/S0960-894X(01)00531-5

Paper

DOI: 10.1016/S0960-894X(01)00531-5

Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives.

Published Oct 8, 2001 · L. X. Zhao, T. S. Kim, S. H. Ahn

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

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2,2′:6′,2′′-terpyridine derivatives show high cytotoxicity against human tumor cells and are potent topoisomerase I inhibitors, offering potential as new anticancer agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1006/BIOO.1999.1152

The Design and Synthesis of Bis-[4′-Azido-2,2′:6′,2″-Terpyridine Platinum(II)] Complexes with Rigid and Extended Linkers for Studying the Topology of DNA by Photoaffinity Labeling☆

Bis-[4′-Azido-2,2′:6′,2′′-terpyridine platinum(II)] complexes with linear linkers of varying lengths can study DNA topology by photoaffinity labeling, allowing for 2D gel electrophoresis analysis.

1999·34citations·G. Lowe et al.·Bioorganic Chemistry

Bioorganic Chemistry

DOI: 10.1016/S0960-894X(99)00375-3

Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.

Beta-substituted polythiophene derivatives, such as carboxaldehyde and hydroxymethyl derivatives of -terthiophene, show potent protein kinase C inhibitory activity.

1999·20citations·W. C. Xu et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1021/JM981074C

Cytotoxicity of (2,2':6',2''-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei.

(2,2':6',2''-terpyridine)platinum(II) complexes show high antiprotozoal activity against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, potentially offering a new treatment for tropical diseases

1999·110citations·Gordon Lowe et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1016/S0960-894X(98)00468-5

Novel protein kinase C inhibitors: α-terthiophene derivatives

-terthiophene derivatives, particularly aldehyde derivatives, show potent protein kinase C inhibitory activity, while being inactive against protein kinase A, mitogen-activated protein kinase, and protein tyrosine kinas

1998·37citations·Darrick S. H. L. Kim et al.·Bioorganic & Medicinal Chemistry Letters

Bioorganic & Medicinal Chemistry Letters

DOI: 10.1021/JA9729589

Oxidation of DNA and RNA by Oxoruthenium(IV) Metallointercalators: Visualizing the Recognition Properties of Dipyridophenazine by High-Resolution Electrophoresis

The cleavage patterns of Ru(tpy)(dppz)O2+ complex reveal its intercalative recognition sites, revealing a complex interaction between DNA and RNA.

1998·80citations·P. Carter et al.·Journal of the American Chemical Society

Journal of the American Chemical Society

Citations

DOI: 10.1016/j.ijbiomac.2024.132792

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M = Fe(III), Ni(II), Cu(II) and Ru(III)) - A comparative analysis.

The novel ester-based terpyridine and its metal complexes show promising binding affinity with DNA/BSA and cytotoxicity against MCF-7 breast cancer cells, comparable to cisplatin.

2024·3citations·Chayan Pandya et al.·International journal of biological macromolecules

International journal of biological macromolecules

DOI: 10.1080/17460441.2022.2017877

Terpyridines as promising antitumor agents: an overview of their discovery and development

Terpyridines show potential as anticancer agents, with their free ligands showing potential for similar or higher anticancer potency than their complexes.

2021·18citations·R. Musioł et al.·Expert Opinion on Drug Discovery

Expert Opinion on Drug Discovery

DOI: 10.1080/00958972.2021.1904234

The effect of substituents on the reactivity of dichloridotriphenylphosphinoruthenium(II) complexes: kinetic and mechanistic study

Substituents on ruthenium(II) complexes affect their reactivity, with complexes 4 and 5 being more reactive than 1, and thiourea nucleophiles playing a key role in substitution reactions.

2021·1citation·Meshack K. Sitati et al.·Journal of Coordination Chemistry

Journal of Coordination Chemistry

DOI: 10.1016/j.ejmech.2020.113032

New derivatives of 4'-phenyl-2,2':6',2″-terpyridine as promising anticancer agents.

Newly synthesized 4′-phenyl-2,2':6′,2′′-terpyridine derivatives show high antiproliferative activity and potential as promising anticancer agents by influencing cellular redox homeostasis.

2020·20citations·K. Malarz et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1021/acscentsci.0c00948

Development of a Platform for Near-Infrared Photoredox Catalysis

Near-infrared photoredox catalysis with minimal energetic waste can efficiently convert near-infrared and deep red light into chemical energy, enabling a wide range of reactions previously requiring higher excitation energy.

2020·82citations·Benjamin D. Ravetz et al.·ACS Central Science

ACS Central Science

DOI: 10.1016/j.ejps.2020.105594

Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs.

Targeting both TopoI and TopoII in anticancer drugs can reduce drug resistance and side effects, making them more efficient and safe.

2020·32citations·Emma Baglini et al.·European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

DOI: 10.1016/j.jinorgbio.2020.111165

Synthesis, characterization, photoluminescence, antiproliferative activity, and DNA interaction of cadmium(II) substituted 4'-phenyl-terpyridine compounds.

Cd(II) substituted 4'-phenyl-terpyridine compounds show excellent antiproliferative activity against human carcinoma cell lines and strong affinity binding with DNA as intercalators.

2020·17citations·Jiahe Li et al.·Journal of inorganic biochemistry

Journal of inorganic biochemistry

DOI: 10.26434/chemrxiv.12124215

Spin-Forbidden Excitation Enables Infrared Photoredox Catalysis

Infrared light can enable molecular scale reactions without intersystem crossing, enabling photoredox catalysis without energy waste.

2020·2citations·T. Rovis et al.

Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2':6',2"-, 2,2':6',3"- and 2,2':6',4"-terpyridine derivatives.

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References

The Design and Synthesis of Bis-[4′-Azido-2,2′:6′,2″-Terpyridine Platinum(II)] Complexes with Rigid and Extended Linkers for Studying the Topology of DNA by Photoaffinity Labeling☆

Bis-[4′-Azido-2,2′:6′,2′′-terpyridine platinum(II)] complexes with linear linkers of varying lengths can study DNA topology by photoaffinity labeling, allowing for 2D gel electrophoresis analysis.

Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives.

Beta-substituted polythiophene derivatives, such as carboxaldehyde and hydroxymethyl derivatives of -terthiophene, show potent protein kinase C inhibitory activity.

Cytotoxicity of (2,2':6',2''-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei.

(2,2':6',2''-terpyridine)platinum(II) complexes show high antiprotozoal activity against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, potentially offering a new treatment for tropical diseases

Novel protein kinase C inhibitors: α-terthiophene derivatives

-terthiophene derivatives, particularly aldehyde derivatives, show potent protein kinase C inhibitory activity, while being inactive against protein kinase A, mitogen-activated protein kinase, and protein tyrosine kinas

Oxidation of DNA and RNA by Oxoruthenium(IV) Metallointercalators: Visualizing the Recognition Properties of Dipyridophenazine by High-Resolution Electrophoresis

The cleavage patterns of Ru(tpy)(dppz)O2+ complex reveal its intercalative recognition sites, revealing a complex interaction between DNA and RNA.

Citations

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M = Fe(III), Ni(II), Cu(II) and Ru(III)) - A comparative analysis.

The novel ester-based terpyridine and its metal complexes show promising binding affinity with DNA/BSA and cytotoxicity against MCF-7 breast cancer cells, comparable to cisplatin.

Terpyridines as promising antitumor agents: an overview of their discovery and development

Terpyridines show potential as anticancer agents, with their free ligands showing potential for similar or higher anticancer potency than their complexes.

The effect of substituents on the reactivity of dichloridotriphenylphosphinoruthenium(II) complexes: kinetic and mechanistic study

Substituents on ruthenium(II) complexes affect their reactivity, with complexes 4 and 5 being more reactive than 1, and thiourea nucleophiles playing a key role in substitution reactions.

New derivatives of 4'-phenyl-2,2':6',2″-terpyridine as promising anticancer agents.

Newly synthesized 4′-phenyl-2,2':6′,2′′-terpyridine derivatives show high antiproliferative activity and potential as promising anticancer agents by influencing cellular redox homeostasis.

Development of a Platform for Near-Infrared Photoredox Catalysis

Near-infrared photoredox catalysis with minimal energetic waste can efficiently convert near-infrared and deep red light into chemical energy, enabling a wide range of reactions previously requiring higher excitation energy.

Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs.

Targeting both TopoI and TopoII in anticancer drugs can reduce drug resistance and side effects, making them more efficient and safe.

Synthesis, characterization, photoluminescence, antiproliferative activity, and DNA interaction of cadmium(II) substituted 4'-phenyl-terpyridine compounds.

Cd(II) substituted 4'-phenyl-terpyridine compounds show excellent antiproliferative activity against human carcinoma cell lines and strong affinity binding with DNA as intercalators.

Spin-Forbidden Excitation Enables Infrared Photoredox Catalysis

Infrared light can enable molecular scale reactions without intersystem crossing, enabling photoredox catalysis without energy waste.

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M = Fe(III), Ni(II), Cu(II) and Ru(III)) - A comparative analysis.