Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

doi:10.1039/C6RA24823C

Paper

Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

Published Jan 4, 2017 · V. Sharma, S. Singh

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90

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0

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Abstract

Dihydropyridine (DHP) is among the most beneficial scaffolds that have revolutionised pharmaceutical research with unprecedented biological properties. Over the years, metamorphosis of easily accessible 1,2- and 1,4-dihydropyridine (1,4-DHP) intermediates by synthetic chemists has generated several drug molecules and natural products such as alkaloids. The 1,4-dihydropyridine (1,4-DHP) moiety itself is the main fulcrum of several approved drugs. The present review aims to collate the literature of 1,2- and the 1,4-DHPs relevant to synthetic and medicinal chemists. We will describe various methodologies that have been used for the synthesis of this class of compounds, including the strategies which can furnish enantiopure DHPs, either by asymmetric synthesis or by chiral resolution. We will also elaborate the significance of DHPs towards the synthesis of natural products of medicinal merit.

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Study Snapshot

1,2- and 1,4-dihydropyridines have revolutionized pharmaceutical research with their biological properties and their use in the synthesis of various drugs and natural products.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis, utility and medicinal importance of 1,2- & 1,4-dihydropyridines

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