Aim To design and synthesize a series of new ethyl 6-bromo-5-hydroxy-1 H -indole-3-carboxylate derivatives and evaluate their anti-influenza virus activity in vitro .Method Nine new compounds were synthesized and their structures were confirmed by IR, 1H-NMR and MS.They were tested for their anti-influenza virus activity in vitro in the cell culture experiments.The viruses were human influenza A3 in MDCK cells and respiratory syncytial virus in HeLa cells respectively.Results and Conclusion All the target compounds showed definite antiviral activity.Some of them,such as compounds Ⅷ 1,Ⅷ 2,Ⅷ 5 were comparable with ribavirin and arbidol.

New ethyl 6-bromo-5-hydroxy-1 H-indole-3-carboxylate derivatives show definite anti-influenza virus activity, with some showing comparable activity to ribavirin and arbidol.

Paper

Synthesis and anti-influenza virus activity of ethyl 6-bromo-5-hydroxy-1 H-indole-3-carboxylate derivatives

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