Synthesis, in vitro and in silico antimalarial activity of 7-chloroquinoline and 4H-chromene conjugates.

doi:10.1016/j.bmcl.2015.08.030

Paper

DOI: 10.1016/j.bmcl.2015.08.030

Synthesis, in vitro and in silico antimalarial activity of 7-chloroquinoline and 4H-chromene conjugates.

Published Oct 15, 2015 · A. Parthiban, J. Muthukumaran, Ashan Manhas

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Chloroquinoline-4H-chromene conjugates incorporating piperizine or azipane tethers show significant antimalarial activity against Plasmodium falciparum strains, potentially targeting the parasite's glycolytic pathway for energy production.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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