Paper

Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido[2,3-b]pyrazin-3(4H)-one derivatives

Published Oct 1, 2011 · DOI · Guo Gang Zhang, Y. Liu, X. Ma

Chinese Chemical Letters

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Abstract

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In Vitro Study

Study Snapshot

Novel 2-hydrazinylpyrido[2,3-b]pyrazin-3(4H)-one derivatives show marked cytotoxicity against A549, MDA-MB-231, and HT-29 cell lines, with 10a emerging as a lead compound.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido[2,3-b]pyrazin-3(4H)-one derivatives

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