A novel α-{[(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1-2H-yl)acetyl]amino}benzylpropanoic acid was synthesized by carbodiimide method from 5-fluorouracil-1-yl acetic acid,N,N′-dicyclohexylcarbo-diimide and L-phenylalanine using 1-hydroxybenzotrizole as an auxiliary reagent.The structure was characterized by IR and elemental analysis.

-[(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1-2H-yl)acetyl]aminobenzylpropanoic acid] shows potential as a novel anti-inflammatory agent.

Paper

Synthesis of α-{[(5-Fluoro-2,4-dioxo-3,4-dihydropyrimidin-1-2H-yl)acetyl]amino}benzylpropanoic Acid

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