Regioselective Synthesis of 2,6‐Dimethyl‐3,5‐bis[(3‐aryl‐5‐trifluoromethyl)‐isoxazol‐4‐carbonyl]‐pyridine Derivatives

doi:10.1002/CJOC.201300366

Paper

Regioselective Synthesis of 2,6‐Dimethyl‐3,5‐bis[(3‐aryl‐5‐trifluoromethyl)‐isoxazol‐4‐carbonyl]‐pyridine Derivatives

Published Jul 1, 2013 · Yi Yang, Min Zhang, Yi‐Wei Zhu

Chinese Journal of Chemistry

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Abstract

Ethyl 4,4,4-trifluoro-3-oxo-butyrate reacted with 2,6-dimethyl-3,5-diacetyl-pyridine 1 in the presence of NaOC2H5 at 0°C to give 2,6-dimethyl-3,5-bis(4,4,4-trifluoro-1,3-oxo-butyl)-pyridine (2a) in good yield. Cyclization reaction of 2a and aryl imidoyl chlorides 5a–5i, obtained from chlorination of aryl oximes with N-chlorosuccimide, afforded 2,6-dimethyl-3,5-bis[(3-aryl-5-trifluoromethyl)-isoxazol-4-carbonyl]-pyridine derivatives 6a–6i.

Study Snapshot

This study demonstrates a method for synthesis of 2,6-dimethyl-3,5-bis(3,4-trifluoromethyl)-isoxazol-4-carbonyl]-pyridine derivatives using ethyl 4,4,4-trifluoro-3-oxo-but

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Regioselective Synthesis of 2,6‐Dimethyl‐3,5‐bis[(3‐aryl‐5‐trifluoromethyl)‐isoxazol‐4‐carbonyl]‐pyridine Derivatives

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References

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This study successfully synthesized ethyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate using regioselective 1,3-dipolar cycloaddition between phenyl nitrile oxide and various 4,4,4

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Citations

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