Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents.

doi:10.1016/j.bmc.2008.11.016

Paper

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents.

Published 2009 · N. Zhang, S. Ayral-Kaloustian, Thai Nguyen

Bioorganic & medicinal chemistry

Q2 SJR score

29

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0

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Abstract

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In Vitro Study

Study Snapshot

The 2-heteroarylpyrimidine series shows potential as potent anti-cancer agents, with compound 21 (PTI-868) showing tumor growth inhibition in nude mouse xenograft models.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents.

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