Synthesis of 1-O-Acetyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxyα,β-D-ribofuranoside

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Synthesis of 1-O-Acetyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxyα,β-D-ribofuranoside

Published 2006 · Shang Zhi-cai

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Abstract

A convenient,high-yield synthesis of 1-O-acetyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxy-α,β-D-ribofuranoside from 2-deoxy-D-ribose was reported.The product was a very important medical intermediate.Its anomers were separated by column chromatography.The optimum conditions were as follows: methyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxy-α,β-D-ribofuranoside:acetic anhydride,1∶4.4;2 mL conc.sulfuric acid;temperature of solution when adding conc.sulfuric acid,(-2°C);hydrolysis temperature,(6°C).The yield was above 84.14%.The separated α and β anomers were characterized by()~1H NMR and melting point.

Study Snapshot

This study presents a high-yield synthesis of 1-O-acetyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxy-,-D-ribofuranoside from 2-deoxy-D-ribose, a

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Synthesis of 1-O-Acetyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxyα,β-D-ribofuranoside

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