Talc mediates angiostasis in malignant pleural effusions via endostatin induction

doi:10.1183/09031936.00061606

Paper

Talc mediates angiostasis in malignant pleural effusions via endostatin induction

Published Apr 1, 2007 · Nasreen Najmunnisa, K. Mohammed, Scott C. Brown

European Respiratory Journal

Q1 SJR score

58

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Abstract

Talc remains the most effective sclerosing agent for pleurodesis. However, its mechanism of action in resolving pleural malignant disease remains unclear. The present study evaluated the angiogenic balance in the pleural space in patients with malignant pleural effusions (MPE) following talc insufflation. Patient pleural fluid samples were collected both before and after talc insufflation. The ability of pleural mesothelial cells (PMC) and malignant mesothelioma cells (MMC) to produce endostatin in vitro was compared. The biological effects of pleural fluids and conditioned media from talc-activated PMC on endothelial cells were evaluated by performing proliferation, invasion, tube formation and apoptosis assays. Pleural fluids from patients with MPE who received thoracoscopic talc insufflation contained significantly higher levels of endostatin (median 16.75 ng·mL−1) compared with pre-talc instillation (1.06 ng·mL−1). Talc-activated PMC released significantly greater amounts of endostatin (mean±sem 1052.39±38.66 pg·mL−1) when compared with a MMC line (134.73±8.72 pg·mL−1). In conlusion, talc alters the angiogenic balance in the pleural space from a biologically active and angiogenic environment to an angiostatic milieu. Functional improvement following talc poudrage in patients with malignant pleural effusions may, in part, reflect these alterations in the pleural space.

In Vitro Study

Rigorous Journal

Study Snapshot

Talc insufflation alters the angiogenic balance in the pleural space, potentially improving functional outcomes in malignant pleural effusion patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Talc mediates angiostasis in malignant pleural effusions via endostatin induction

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References

Management of Malignant Pleural Effusions

Tunneled pleural drainage catheters effectively control symptoms in 80 to 100% of patients with malignant pleural effusions, making them a recommended outpatient treatment option.

Effektivität und zugrunde liegende Mechanismen der Talkumpleurodese bei malignem Pleuraerguss

Talkumpleurodesis is a safe and effective method for controlling malignant pleural effusions, with a success rate of over 90%.

Nuclear Factor-κB Affects Tumor Progression in a Mouse Model of Malignant Pleural Effusion

NF-B inhibition in lung cancer cells can decrease tumor burden, pleural effusion volume, and TNF- levels, potentially reducing malignant pleural effusion progression.

Prolonged survival after talc poudrage for malignant pleural mesothelioma: Case series

Talc poudrage is a promising palliative option for malignant pleural mesothelioma patients, with prolonged survival rates compared to other published series.

Clinical efficacy and safety of thoracoscopic talc pleurodesis in malignant pleural effusions.

Thoracoscopic talc pleurodesis is a safe and effective method to stop recurrent malignant pleural effusions, resulting in lasting pleural symphysis.

Citations