Tandem mass spectrometric determination of 11-dehydrothromboxane B2, an index metabolite of thromboxane B2 in plasma and urine.

doi:10.1016/0003-2697(87)90380-0

Paper

Tandem mass spectrometric determination of 11-dehydrothromboxane B2, an index metabolite of thromboxane B2 in plasma and urine.

Published Jul 1, 1987 · H. Schweer, C. Meese, O. Fürst

Analytical biochemistry

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61

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1

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Observational Study

Study Snapshot

11-dehydrothromboxane B2 is the best index metabolite for measuring systemic thromboxane A2 activity in plasma and urine, with high selectivity using triple-stage quadrupole mass spectrometry.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Tandem mass spectrometric determination of 11-dehydrothromboxane B2, an index metabolite of thromboxane B2 in plasma and urine.

References

Citations

Methods of the Analysis of Oxylipins in Biological Samples

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Cigarette smoking aggravates COX-1-mediated platelet reactivity in young, otherwise healthy, smoking men.

Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

Paracetamol does not increase oxidative stress in humans, as it inhibits prostacyclin synthesis and increases nitric oxide synthesis, without affecting thromboxane or COX activity.

Simultaneous quantification of 8-iso-prostaglandin-F(2alpha) and 11-dehydro thromboxane B(2) in human urine by liquid chromatography-tandem mass spectrometry.

This study developed a sensitive, precise, and rapid method for simultaneous determination of 8-iso-PGF2 and 11-DH-TXB2 in human urine samples, enabling evaluation of oxidative stress and platelet aggregation.