tert-Butyl acetothioacetate and its use in synthesis: 3-Acetyl-4-hydroxy-5,5-dimethylfuran-2(4H)-one 
 
 
 
intermediate: S-tert-butyl 3-oxobutanthioate 
 
 
 
 
intermediate: 1-Carbomethoxy-1-methylethyl 3-oxobutanoate. 
 
 
 
 
product: 3-Acetyl-4-hydroxy-5,5-dimethylfuran-2(5H)-one. 
 
 
 
 
 
Keywords: 
 
acylation; 
acylation; 
addition, to CO; 
annulation, heterocyclic-[5]; 
cyclization, condensation; 
ring opening reactions; 
transesterification; 
silver(I) trifluoroacetate; 
tetrahydrofuran; 
mercaptans, stench

Tert-Butyl Acetothioacetate is used in the synthesis of 3-Acetyl-4-hydroxy-5,5-dimethylfuran-2(4H)-one, a compound with a strong odor.

Paper

tert‐Butyl Acetothioacetate and Its Use in Synthesis: 3‐Acetyl‐4‐hydroxy‐5,5‐dimethylfuran‐2(4H)‐one

References

Citations