TERT-Butyl amides resulting from UgiMCR of T-BuNC and 5-substituted-1 H-pyrazole-3-carboxylic acids with variousaldehydes and amines undergo cyclization into 5,6-dihydropyrazolo[1,5- A]pyrazine-4,7-diones in glacialacetic acid under microwave irradiation. This reaction is a remarkablecase of neighboring-group-assisted cleavage of TERT-butylamides and demonstrates utility of T-BuNCas a new convertible isocyanide.

T-BuNC acts as a new convertible isocyanide in the Ugi Reaction, enabling the preparation of 5,6-dihydropyrazolo[1,5-a]pyrazine-4,7-diones under microwave irradiation.

Paper

tert-ButylIsocyanide as a Convertible Reagent in Ugi Reaction: Microwave-AssistedPreparation of 5,6-Dihydropyrazolo[1,5-a]pyrazine-4,7-diones

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