Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

doi:10.1016/j.bioorg.2019.102982

Paper

Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Published Aug 1, 2019 · Nika Strašek, Lara Lavrencic, Andraž Oštrek

Bioorganic chemistry

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Abstract

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In Vitro Study

Study Snapshot

Methyl esters of tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates show high activity in inhibiting Plasmodium falciparum dihydroorotate dehydrogenase, with high selectivity against

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

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References

Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors.

Novel 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives show moderate inhibition activity against cathepsin K, offering potential therapeutic applications.

Copper-Catalyzed Azomethine Imine–Alkyne Cycloadditions (CuAIAC)

CuAIAC reaction shows promise for organic synthesis and 'click' chemistry, with potential applications in azomethine imine-alkyne cycloadditions and related reactions.

Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria.

The Plasmodium falciparum dihydroorotate dehydrogenase is a promising target for developing new antimalarial drugs, as it inhibits de novo pyrimidine biosynthesis and prevents malarial infection.

Metal-catalyzed [3+2] cycloadditions of azomethine imines

Metal-catalyzed [3+2] cycloadditions of azomethine imines offer a regioselective and stereoselective method for the synthesis of pyrazolidines and pyrazolines.

Synthesis of Non-Racemic Pyrazolines and Pyrazolidines by [3+2] Cycloadditions of Azomethine Imines

This review highlights the development of efficient, mild, and selective methods for the synthesis of non-racemic pyrazolines and pyrazolidines using metal- and organocatalyzed transformations.

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