Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.

doi:10.1016/S0024-3205(03)00139-5

Paper

Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.

Published Apr 18, 2003 · Zhaohui Zhang, T. Wei, J. Hou

Life sciences

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78

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2

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Abstract

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In Vitro Study

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Study Snapshot

Tetramethylpyrazine effectively protects against ischemic brain injury by scavenging reactive oxygen species and regulating nitric oxide production, potentially preventing peroxynitrite formation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.

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References

Citations

Bibliometric analysis of research progress on tetramethylpyrazine and its effects on ischemia-reperfusion injury.

TMP shows significant protective effects on ischemia-reperfusion injury, but its bioavailability needs improvement for clinical applications.

Design, synthesis and biological evaluation of new multi-target scutellarein hybrids for treatment of Alzheimer's disease.

Compound 11e, a multi-target scutellarein hybrid, shows promising potential for Alzheimer's disease therapy by inhibiting -amyloid aggregation, reducing tau protein hyperphosphorylation, and exhibiting neuroprotective properties.

Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review

TMP, found in Ligusticum striatum DC, shows potential in treating central nervous system diseases by inhibiting calcium ion overload, glutamate excitotoxicity, and promoting synaptic plasticity.

Coffee Roasting and Extraction as a Factor in Cold Brew Coffee Quality

Cold brew coffees are an exceptional source of chlorogenic acid, offering a natural alternative to energy drinks, and the best option for production is beans roasted in the 210-220°C temperature range.

Ultrasound/microbubble-mediated tetramethylpyrazine for neuroprotection against cerebral ischemia/reperfusion-injured rat brain

The combined use of TMP and ultrasound-activated microbubble destruction shows promising neuroprotection against cerebral ischemia/reperfusion injury, reducing infarct volume and increasing Nissl-positive neurons.