Paper

The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.

Published Jun 1, 2017 · A. Albassam, R. Frye, J. Markowitz

Chemico-biological interactions

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Abstract

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In Vitro Study

Study Snapshot

Isosilibinin and isosilybin B from milk thistle have a significant inhibitory effect on CYP2C8 enzyme activity in vitro, but their bioavailability in humans is likely limited due to poor bioavailability of flavonolignans.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.

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