Paper
The effect of vitamin D supplementation on glycemic status of elderly people with prediabetes: a 12-month open-label, randomized-controlled study
Published Jan 2, 2022 · E. Zaromitidou, T. Koufakis, G. Dimakopoulos
Expert Review of Clinical Pharmacology
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Abstract
ABSTRACT Background Data on the efficacy of vitamin D in improving the glycemic status of elderly people with prediabetes are scarce. This open-label, randomized-controlled trial investigated the effect of vitamin D supplementation on glycemic markers of Greek people with prediabetes aged 60 years or above, over 12 months. Research design and methods Participants were randomized to a weekly vitamin D3 dose of 25,000 IU (n = 45) or nothing (n = 45), on top of lifestyle measures. Anthropometric and glycemic markers were assessed at baseline, 3, 6, and 12 months Results Supplemented participants demonstrated a significant increase in 25(OH)D concentrations at 3, 6, and 12 months compared to baseline . In the intervention group, fasting glucose was decreased at 6 months compared to baseline (96.12 ± 5.51 vs 103.40 ± 12.05 mg/dl, p < 0.01) and glycated hemoglobin was significantly lower at 6 and 12 months compared to baseline [5.82 ± 0.21% vs 5.87 ± 0.21%, p = 0.004 and 5.80 ± 0.23% vs 5.87 ± 0.21%, p < 0.001, respectively]. Conclusions Vitamin D could be complementary to lifestyle change strategy for the management of prediabetes in the elderly. Clinical trial registration ISRCTN51643592.
RCTVitamin D supplementation can improve glycemic status in elderly people with prediabetes, potentially complementing lifestyle changes in managing this condition.
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