Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice.

doi:10.1016/S0025-6196(11)63701-4

Paper

DOI: 10.1016/S0025-6196(11)63701-4

Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice.

Published Apr 1, 1998 · Robert Vassallo, J. J. Lipsky

Mayo Clinic proceedings

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Abstract

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Study Snapshot

Theophylline has immunomodulatory and anti-inflammatory properties, and may be used in future for treating bradyarrhythmias after cardiac transplantation, reducing nephropathy from contrast material, and treating breathing problems during sleep.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1164/ARRD.1985.131.1.22

Sustained-release theophylline reduces dyspnea in nonreversible obstructive airway disease.

Sustained-release theophylline significantly reduces dyspnea in ambulatory patients with moderate to severe nonreversible airway obstruction without altering lung function, gas exchange, or exercise performance.

2015·119citations·D. Mahler et al.·The American review of respiratory disease

The American review of respiratory disease

DOI: 10.1016/S0008-6363(96)00159-9

Differential antagonism of cardiac actions of adenosine by theophylline.

Theophylline completely antagonizes A1-adenosine receptor-mediated prolongation of the A-H interval but has minimal effect on A2-receptor-mediated coronary vasodilation in man.

1996·12citations·B. Bertolet et al.·Cardiovascular research

Cardiovascular research

DOI:

Posttransplant erythrocytosis: a model for the investigation of the pharmacological control of renal erythropoietin production?

Posttransplant erythrocytosis should not be used as a model disease for studying physiological control of renal erythropoietin production, as its treatment with low doses of ACEI is reliable.

1996·11citations·Gleiter Ch·International journal of clinical pharmacology and therapeutics

International journal of clinical pharmacology and therapeutics

DOI: 10.1182/BLOOD.V88.6.2172.BLOODJOURNAL8862172

Theophylline synergizes with chlorambucil in inducing apoptosis of B-chronic lymphocytic leukemia cells.

Theophylline and chlorambucil effectively synergize in inducing apoptosis in B-chronic lymphocytic leukemia cells, suggesting potential therapeutic value in this setting.

1996·94citations·F. Mentz et al.·Blood

Blood

DOI: 10.1002/j.1875-9114.1996.tb02995.x

Prospective Evaluation of Two Dosing Equations for Theophylline in Premature Infants

Two dosing equations for theophylline in premature infants can predict maintenance dosages and achieve target serum concentrations, with minimal further adjustments needed.

1996·5citations·V. Bhatt-Mehta et al.·Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Citations

DOI: 10.3389/fcvm.2024.1412376

Oral theophylline corrects sinus node dysfunction in acute on chronic lithium toxicity: case report and systematic review of lithium-induced Sinus node dysfunction

Oral theophylline effectively corrects sinus node dysfunction in patients with acute lithium toxicity, potentially avoiding more invasive measures like hemodialysis, temporary pacing, or permanent pacemaker implantation.

2024·1citation·Martina Nesti et al.·Frontiers in Cardiovascular Medicine

Frontiers in Cardiovascular Medicine

DOI: 10.3390/ijms23084167

Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies

Theophylline shows potential as an adjuvant in COVID-19 treatment through bronchodilation, immunomodulation, and potentially antiviral mechanisms, but computational studies are needed to understand its behavior and effects.

2022·23citations·L. Montaño et al.·International Journal of Molecular Sciences

International Journal of Molecular Sciences

DOI: 10.3390/molecules27082456

A Disposable Sensor Chip Using a Paste Electrode with Surface-Imprinted Graphite Particles for Rapid and Reagentless Monitoring of Theophylline

The carbon-paste electrode with surface-imprinted graphite particles provides rapid and reagentless monitoring of theophylline, offering potential as a drug sensor for clinical use.

2022·4citations·Aaryashree et al.·Molecules

Molecules

DOI: 10.3390/s20205847

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

The disposable MIP-sensor offers quick and straightforward therapeutic drug monitoring, with higher sensitivity and linearity than non-imprinted polymer sensors, preventing toxic side effects and insufficient therapeutic effects.

2020·16citations·Aaryashree et al.·Sensors (Basel, Switzerland)

Sensors (Basel, Switzerland)

DOI: 10.18203/2319-2003.ijbcp20203150

Possible treatments of COVID-19 present and future

COVID-19 treatment options include vaccines, antiviral drugs, and immunotherapy, but currently there is no effective treatment available.

2020·0citations·S. Islam·International journal of basic and clinical pharmacology

International journal of basic and clinical pharmacology

DOI: 10.1007/978-1-84628-715-2_109

Chronic Obstructive Pulmonary Disease

COPD is a progressive, disabling disorder caused by smoking and age-related decline in lung function, and can be diagnosed through pulmonary function testing.

2020·0citations·R. Estrada-Y.-Martin et al.