Paper
Theoretical Explanation for Reduced Body Mass Index and Obesity Rates in Cannabis Users
Published Jul 11, 2018 · T. Clark, Jessica M. Jones, Alexis G. Hall
Cannabis and Cannabinoid Research
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Abstract
Abstract Introduction: Obesity is treatment-resistant, and is linked with a number of serious, chronic diseases. Adult obesity rates in the United States have tripled since the early 1960s. Recent reviews show that an increased ratio of omega-6 to omega-3 fatty acids contributes to obesity rates by increasing levels of the endocannabinoid signals AEA and 2-AG, overstimulating CB1R and leading to increased caloric intake, reduced metabolic rates, and weight gain. Cannabis, or THC, also stimulates CB1R and increases caloric intake during acute exposures. Goals: To establish the relationship between Cannabis use and body mass index, and to provide a theoretical explanation for this relationship. Results: The present meta-analysis reveals significantly reduced body mass index and rates of obesity in Cannabis users, in conjunction with increased caloric intake. Theoretical explanation: We provide for the first time a causative explanation for this paradox, in which rapid and long-lasting downregulation of CB1R following acute Cannabis consumption reduces energy storage and increases metabolic rates, thus reversing the impact on body mass index of elevated dietary omega-6/omega-3 ratios.
Cannabis use reduces body mass index and obesity rates due to rapid and long-lasting downregulation of CB1R, which reduces energy storage and increases metabolic rates, reversing the impact of elevated dietary omega-6/omega-3 ratios.
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