Paper
THIETHYLPERAZINE: A CLINICAL INVESTIGATION OF A NEW ANTI-EMETIC DRUG
Published 1964 · Cyril Taylor, V. K. Stoelting
Survey of Anesthesiology
0
Citations
0
Influential Citations
Abstract
A new phenothiazine compound, thiethylperazine malate, was investigated with regard to its effectiveness in preventing postoperative emesis and to its side-effects. A double-blind technique was employed. Thiethylperazine or a placebo was injected intramuscularly at the termination of anaesthesia, and the patient was observed in the recovery room for two hours. There was a significant reduction in the incidence of postoperative emesis in patients who had received 5.0 mg. or 10.0 mg. of thiethylperazine. There was a slight prolongation of postanaesthetic somnolence by the drug. Hypotension, greater than 30 mm. Hg, was more frequent in the group of patients who had received 10.0 mg. of thiethylperazine. No other side-effects were detected. Thiethylperazine appeared to be a very useful anti-emetic, and is a forward step in the drive to find one with maximal efficiency and minimal side-effects.
Thiethylperazine malate effectively reduces postoperative emesis without significant side-effects, making it a promising new anti-emetic drug.
Full text analysis coming soon...