Thiocyanate equally increases affinity for two DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor states.

doi:10.1016/s0026-895x(25)13633-x

Paper

DOI: 10.1016/s0026-895x(25)13633-x

Thiocyanate equally increases affinity for two DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor states.

Published Mar 1, 1993 · Randy A. Hall, G. Massicotte, M. Kessler

Molecular pharmacology

Q1 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Thiocyanate enhances AMPA binding by equally increasing the affinities of both high and low affinity states of AMPA receptors, not by converting low affinity receptors into the high affinity state.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/0304-3940(93)90113-Y

Single channel recordings of reconstituted AMPA receptors reveal low and high conductance states

Reconstituted AMPA receptors show two distinct conductance levels, 12 and 60 pS, with most of them belonging to the former variety, suggesting regulation of binding and conductance properties.

1993·18citations·V. Vodyanoy et al.·Neuroscience Letters

Neuroscience Letters

DOI: 10.1111/j.1471-4159.1992.tb10086.x

Evidence that High‐ and Low‐Affinity DL‐α‐Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid (AMPA) Binding Sites Reflect Membrane‐Dependent States of a Single Receptor

The high- and low-affinity components of AMPA binding are inter-convertible states of a single receptor, with the conversion occurring upon insertion into synapses.

1992·68citations·R. Hall et al.·Journal of Neurochemistry

Journal of Neurochemistry

DOI: 10.1073/PNAS.89.15.6881

Increasing binding affinity of agonists to glutamate receptors increases synaptic responses at glutamatergic synapses.

Increasing the affinity of glutamate agonists for AMPA receptors leads to increased synaptic responses, suggesting modifications in AMPA receptor characteristics after long-term potentiation.

1992·33citations·K. Shahi et al.·Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

DOI: 10.1016/s0026-895x(25)09124-2

Multiple states of rat brain (RS)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors as revealed by quantitative autoradiography.

[3H]AMPA binds to two affinity conformations of postsynaptic binding sites in the rat brain, with potassium thiocyanate increasing the affinity of low affinity binding.

1992·33citations·J. Cha et al.·Molecular pharmacology

Molecular pharmacology

DOI: 10.1016/0896-6273(91)90175-Y

Kinetic analysis of interactions between kainate and AMPA: Evidence for activation of a single receptor in mouse hippocampal neurons

AMPA activates a single receptor in mouse hippocampal neurons, while kainate reduces the amplitude and onset of desensitization in AMPA-induced responses.

1991·245citations·D. K. Patneau et al.·Neuron

Neuron

Citations

DOI: 10.14252/FOODSAFETYFSCJ.2014036

The Acute Encephalopathy Induced by Intake of Sugihiratake Mushroom in the Patients with Renal Damage Might Be Associated with the Intoxication of Cyanide and Thiocyanate

Sugihiratake mushroom intake in patients with chronic renal failure may cause acute encephalopathy due to intoxication of cyanide and thiocyanate, potentially causing kidney damage.

2015·7citations·H. Akiyama et al.

DOI: 10.1016/j.euroneuro.2008.08.010

Effects of risperidone on glutamate receptor subtypes in developing rat brain

Risperidone has dose-dependent effects on glutamate receptor subtypes in developing animals, with different responses in juvenile animals than adults.

2009·29citations·Y. Choi et al.·European Neuropsychopharmacology

European Neuropsychopharmacology

DOI: 10.1016/j.neuint.2008.02.009

Physiological significance of high- and low-affinity agonist binding to neuronal and recombinant AMPA receptors

The high-affinity binding in AMPA receptors is an immature variant that does not contribute to currents in cells, and functional low-affinity receptors are present in such small numbers that they mask their presence in binding assays.

2008·12citations·M. Kessler et al.·Neurochemistry International

Neurochemistry International

DOI: 10.1016/j.euroneuro.2006.10.004

Effects of risperidone on dopamine receptor subtypes in developing rat brain

Risperidone has dose-dependent effects on dopamine receptors in developing animals, with juvenile animals being more sensitive to its cerebral effects than adults.

2007·54citations·T. Moran-Gates et al.·European Neuropsychopharmacology

European Neuropsychopharmacology

DOI: 10.1016/j.brainres.2005.09.024

Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators

[3H]fluorowillardiine binding tests can provide valuable information on drug-receptor and drug-drug interactions for a wide range of modulatory agents.

2006·19citations·M. Kessler et al.·Brain Research

Brain Research