Paper
Thiourea and thiosemicarbazide derivatives structurally related to hexestrol: synthesis and anticancer and other pharmacological properties.
Published Sep 1, 1981 · A. Omar, A. M. Farghaly, A. A. Hazzai
Journal of pharmaceutical sciences
Q2 SJR score
16
Citations
0
Influential Citations
Abstract
Two novel series of thio compounds bearing internal structural modifications of hexestrol were synthesized as potential anticancer agents. The first contains several N-substituted thiourea functions, and the second contains various N4-substituted-3-thiosemicarbazide moieties in place of one alpha-ethyl group of hexestrol dimethyl ether. The products showed no antileukemic activity in the P-388 lymphocytic leukemia system and did not exhibit any anticonvulsant or estrogenic properties.
In Vitro StudyStudy Snapshot
Thiourea and thiosemicarbazide derivatives show no antileukemic activity and no anticonvulsant or estrogenic properties, suggesting their potential as potential anticancer agents.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Novel potential anticancer agents derived from benzimidazole.
Novel benzimidazole derivatives showed no significant antileukemic activity against P-388 lymphocytic leukemia.
1980·19citations·E. S. Ibrahim et al.·Journal of pharmaceutical sciences
Journal of pharmaceutical sciences
The cyelodesulfurization of thio-compounds. Part XVII. Synthesis of some novel 2-substituted amino-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones by cyelodesulfurization of thiosemicarbazides with dicyclohexylearbodiimide (DCCD)
This study demonstrates a simple method for synthesizing novel 2-substituted amino-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones by cyelodesulfurization of thiosemicarbazides with dicycl
1979·13citations·A. Omar et al.·Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry
New biphenyl derivatives i: 1-(4-biphenylyl)-2-phenylethylamines as potential antispasmodic and cardiovascular agents.
The new biphenyl derivatives show potential as antispasmodic and cardiovascular agents due to their nonspecific inhibitory action on smooth muscles.
1978·5citations·R. Shafik et al.·Journal of pharmaceutical sciences
Journal of pharmaceutical sciences
Elucidation of the structure of the antineoplastic agents, 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones.
The antineoplastic agents 2-formylpyridine and 1-formylisoquinoline thiosemicarbazones are mainly E-configuration isomers with minor amounts of Z isomers, with minor amounts of Z isomers in their literature tested carcinostatic activity.
1977·54citations·I. Antonini et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Inhibition of tumor cell transplantability by iron and copper complexes of 5-substituted 2-formylpyridine thiosemicarbazones.
Copper and iron complexes of 5-substituted 2-formylpyridine thiosemicarbazones effectively inhibit tumor cell transplantation, potentially preventing tumor growth in new hosts.
1976·104citations·W. Antholine et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Citations
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2020·8citations·Saeed Ghasemi et al.·Advanced Pharmaceutical Bulletin
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Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry
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2013·3citations·Saeed Ghasemi et al.·Australian Journal of Chemistry
Australian Journal of Chemistry
Highly efficient and catalyst-free synthesis of substituted thioureas in water
This study presents a highly efficient and catalyst-free method for the synthesis of substituted thiourea derivatives in water, yielding both unsymmetrical and symmetrical structures in good to excellent yields.
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New Thiazolidinone and Triazinethione Conjugates Derived from Amino-β-lactams.
Thioureas 3a-s can be used to create various iminothiazolidinones and triazinethiones, with varying regioselectivity and regioselectivity.
2009·8citations·Katarina Radolović et al.·ChemInform
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Highly efficient and catalyst-free synthesis of unsymmetrical thioureas under solvent-free conditions
This study presents a catalyst-free, solvent-free method for synthesising unsymmetrical thioureas with high yields and short reaction time, without forming symmetric disubstituted thioureas.
2009·48citations·A. Halimehjani et al.·Tetrahedron Letters
Tetrahedron Letters
An efficient method for the synthesis of disubstituted thioureas via the reaction of N,N'-di-Boc-substituted thiourea with alkyl and aryl amines under mild conditions
This study developed an efficient method for the synthesis of disubstituted thioureas under mild conditions, allowing for the incorporation of functional groups such as amide, ester, enol ether, and hydroxyl groups.
2008·20citations·Biaolin Yin et al.·Tetrahedron Letters
Tetrahedron Letters