Three-Component Cascade Bis-heteroannulation of Aryl or Vinyl Methylketoxime Acetates toward Thieno[3,2-c]isoquinolines.

doi:10.1021/acs.orglett.9b03241

Paper

Three-Component Cascade Bis-heteroannulation of Aryl or Vinyl Methylketoxime Acetates toward Thieno[3,2-c]isoquinolines.

Published Oct 16, 2019 · Zhenhua Xu, G. Deng, Feng Zhang

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37

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Abstract

A three-component cascade bis-heteroannulation reaction is described that provides access to a variety of benzo[4,5]thieno[3,2-c]isoquinoline and thieno[3,2-c]isoquinoline compounds from easily available methylketoximes, o-halobenzaldehydes, and elemental sulfur. Mechanistic studies reveal a two-step process involving a sequential copper and sulfur catalysis relay.

Study Snapshot

This three-component cascade bis-heteroannulation reaction allows for the synthesis of various benzo[4,5]thieno[3,2-c]isoquinoline and thieno[3,2-c]isoquinoline compounds using readily available methylketoximes, o-halobenz

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Three-Component Cascade Bis-heteroannulation of Aryl or Vinyl Methylketoxime Acetates toward Thieno[3,2-c]isoquinolines.

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