Three-component condensation of 4-aminoisothiazole derivatives with aldehydes and Meldrum’s acid. Synthesis of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones

doi:10.1007/S11172-009-0211-3

Paper

Three-component condensation of 4-aminoisothiazole derivatives with aldehydes and Meldrum’s acid. Synthesis of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones

Published Jul 1, 2009 · B. Lichitsky, A. Komogortsev, R. M. Belyi

Russian Chemical Bulletin

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6

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Abstract

A convenient method was developed for the synthesis of previously unknown substituted 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones based on the three-component condensation of 4-aminoisothiazole hydrochlorides, Meldrum’s acid, and aromatic aldehydes.

Study Snapshot

This method allows for the synthesis of novel substituted 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones by combining 4-aminoisothiazole hydrochlorides, Meldrum's acid, and aromatic aldehydes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Three-component condensation of 4-aminoisothiazole derivatives with aldehydes and Meldrum’s acid. Synthesis of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones

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References

Three-Component Condensation of 2,4-Diaminoselenazole with Aldehydes and Meldrum’s Acid: Synthesis of 7-Aryl(alkyl)-Substituted 2-Amino-6,7-dihydro-4H-selenazolo[4,5-b]pyridin-5-ones

This method allows for the synthesis of 7-aryl(alkyl)-substituted 2-amino-6,7-dihydro-4H-selenazolo [4,5-b]pyridin-5-ones by combining 2,4-diaminoselenazole

Three-component condensation of 2,4-diaminothiazoles with aldehydes and Meldrum's acid: synthesis of 7-aryl(alkyl)-substituted 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones

This study presents a new method for synthesizing 6,7-dihydro-4H-thiazolo[4,5-b]pyridin-5-ones by decarboxylating 2,4-diamino-5-thiazolecarboxylic acids and reacting with aldeh

DNA binding ligands targeting drug-resistant bacteria: structure, activity, and pharmacology.

DNA minor-groove binding ligands show potential as a novel antibacterial treatment for drug-resistant bacteria, with improved in vivo tolerability and in vitro antibacterial potency against a broad range of Gram-positive pathogens.

DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria.

Minor-groove binding ligands show excellent antibiotic potency against drug-resistant Gram-positive bacteria, with no cross-resistance to known antibacterial drugs.

Ring transformation of 3-hydroxy-1,2,5- and -1,2,4-thiadiazoles and -isothiazoles into isothiazole, thiazole and thiophene derivatives

Ring transformation of 3-hydroxy-1,2,5- and -1,2,4-thiadiazoles and -isothiazoles into isothiazole, thiazole, and thiophene derivatives can be achieved by reacting with acetic anhydride in the presence of DBU.

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