TOXICITY OF 2-CHLOROBENZYLIDENE MALONONITRILE AND HEPATIC MICROSOMAL MIXED FUNCTION OXIDASE SYSTEM

doi:10.1016/B978-0-12-187702-6.50065-7

Paper

TOXICITY OF 2-CHLOROBENZYLIDENE MALONONITRILE AND HEPATIC MICROSOMAL MIXED FUNCTION OXIDASE SYSTEM

Published 1980 · S. S. Pawar, M. S. Kachole, U. K. Halde

Microsomes, Drug Oxidations and Chemical Carcinogenesis

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Abstract

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Study Snapshot

2–chlorobenzylidene malononitrile and its metabolites impair cytochrome P-450 structure and function, while microsomal protein levels remain unaltered, and cyanide directly affects the mixed function oxidase system.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

TOXICITY OF 2-CHLOROBENZYLIDENE MALONONITRILE AND HEPATIC MICROSOMAL MIXED FUNCTION OXIDASE SYSTEM

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