Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat.

doi:10.1016/J.TAAP.2007.08.017

Paper

Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat.

Published Dec 1, 2007 · P. Hendriksen, A. Freidig, D. Jonker

Toxicology and applied pharmacology

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26

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Methyl mercury, benzene, and trichloroethylene interact to cause synergistic effects on gene expression in rat liver and kidney, indicating a shift from compound-specific responses to generic stress responses in mixtures.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat.

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