Meso-3,5-bis(trifluoromethyl)phenyl picket calix[4]pyrrole 1 displays excellent fluoride anion transport activity across artificial lipid bilayers showing EC50 = 2.15 μM (at 450 s in EYPC vesicle) with high fluoride over chloride ion selectivity. The high fluoride selectivity of 1 was ascribed to the formation of a sandwich type π-anion-π interaction complex.

Meso-3,5-bis(trifluoromethyl)phenyl picket calix[4]pyrrole 1 shows excellent fluoride anion transport activity across artificial lipid bilayers, with high fluoride over chloride ion selectivity.

Paper

Transmembrane fluoride anion transport by meso-3,5-bis(trifluoromethyl)phenyl picket calix[4]pyrrole.

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