Trifluoromethyl ketones (TFMKs) are exceedingly valuable synthetic targets in their own right and as synthons in the construction of fluorinated pharmacons. This Feature Article provides an overview of the properties of TFMKs, an in-depth discussion of the methods available for their synthesis, and two illustrative examples of their application as key intermediates in medicinal chemistry.

Trifluoromethyl ketones (TFMKs) are valuable synthetic targets and key intermediates in medicinal chemistry, with applications in fluorinated pharmacons and pharmaceutical synthesis.

Paper

Trifluoromethyl ketones: properties, preparation, and application.

References

Citations