Trimethylchlorosilane-Mediated Mild α-Chlorination of 1,3-Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate

doi:10.1055/s-0035-1561572

Paper

Trimethylchlorosilane-Mediated Mild α-Chlorination of 1,3-Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate

Published Mar 2, 2016 · Siying Chong, Yingpeng Su, Liliu Wu

Synthesis

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Abstract

Abstract Trimethylchlorosilane was used as chlorine source for the α-chlorination of 1,3-dicarbonyl compounds with phenyliodonium diacetate as oxidant at room temperature. The reaction allows the selective synthesis of α-monochlorinated products from different kinds of 1,3-dicarbonyl compounds in good yield. The potential possibility of this conversion for bromination has also been investigated.

Study Snapshot

Trimethylchlorosilane-mediated mild -chlorination of 1,3-dicarbonyl compounds with phenyliodonium diacetate allows for selective synthesis of -monochlorinated products in good yield, potentially enabling bromination conversion.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Trimethylchlorosilane-Mediated Mild α-Chlorination of 1,3-Dicarbonyl Compounds Promoted by Phenyliodonium Diacetate

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References

Medicinal Chemistry: An Introduction

This book provides an introduction to medicinal chemistry, covering drug discovery, design, metabolism, enzymes, receptors, and nitric oxide.

Hypervalent iodine in organic synthesis

Hypervalent iodine reagents can be used in organic synthesis to perform various transformations, such as acetoxylation, phenolic oxidation, and nitrogen compound oxidation.

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