A series of triphenylphosphinecarboxamide (TPPc) derivatives were designed and synthesized as alternative reagents to triphenylphosphine for the facile reduction of azides. The TPPc derivatives performed as efficient reducing agents for the synthesis of primary amines without the need for an additional hydrolysis procedure. The TPPc derivatives were also applied to nucleic acid sensing using a RhAz-oligonucleotide conjugate in a DNA-templated fluorogenic reaction.

Triphenylphosphinecarboxamide derivatives are efficient reducing agents for azides and can be applied to nucleic acid detection without additional hydrolysis procedures.

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Triphenylphosphinecarboxamide: an effective reagent for the reduction of azides and its application to nucleic acid detection.

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