Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.

Triphenylphosphine-catalyzed amide bond formation between carboxylic acids and amines allows for the synthesis of new compounds with improved properties.

Paper

Triphenylphosphine-catalysed amide bond formation between carboxylic acids and amines.

References

Citations