Paper
A convenient two-step synthesis of 6-methylenesubstituted-4-trichloromethyl-2-methylsulfanyl pyrimidines
Published Jan 23, 2006 · N. Zanatta, D. Flores, C. C. Madruga
Tetrahedron Letters
Q3 SJR score
18
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
This study presents a two-step synthetic strategy for obtaining 6-methylenesubstituted-4-trichloromethyl-2-methylsulfanylpyrimidines from cyclization of 5-bromo-4-methoxy-1,1,1-trichloro-pent-3-en-2
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Citations
Novel pyrimidine derivatives: Synthesis, Molecular Docking Studies, and structure activity relationship
Novel 5-substituted uracils 3a, b show potential as EGFR small molecule therapies for lung cancer, with molecular docking studies suggesting their potential for treating cancers with mutations in EGFR.
2023·1citation·Bassant Abdo·Bulletin of Faculty of Science, Zagazig University
Bulletin of Faculty of Science, Zagazig University
Chemoselective O-Alkylation of 4-(Trifluoromethyl)pyrimidin-2(1H)-ones Using 4-(Iodomethyl)pyrimidines
Direct chemoselective O-alkylation using 4-(iodomethyl)pyrimidines provides 70-98% yields of 18 O-alkyl derivatives of 6-substituted-4-(trifluoromethyl)pyrimidin-(1H)-ones, with
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Polyfluoromethyl-substituted pyrimidines and pyrazoles with potential for further functionalization were synthesized from fluoroalkyl-containing enones, with potential for further functionalization of the hydroxymethyl group.
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