Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model.

doi:10.1016/j.matbio.2018.03.008

Paper

Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model.

Published Mar 15, 2018 · Sanne D’hondt, Brecht Guillemyn, D. Syx

Matrix biology : journal of the International Society for Matrix Biology

Q1 SJR score

58

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4

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Abstract

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Non-RCT

Animal Study

Study Snapshot

A mutant type III collagen model demonstrates a key role for type III collagen in collagen fibrillogenesis in dermal and arterial tissues, causing severe skin wounds and early death in mice.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Type III collagen affects dermal and vascular collagen fibrillogenesis and tissue integrity in a mutant Col3a1 transgenic mouse model.

References

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