Paper
Ultra-short acting neuromuscular blocking agents; di- and trisubstituted benzyl bisquaternary ammonium derivatives of bis(tropan-3α-ol)-diesters
Published 2002 · L. Gyermek, Ching-Li Leet, Young-moon Cho
Medicinal Chemistry Research
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Abstract
Based on previous experiences with bisquatemary ammonium derivatives of bistropine esters of dicarboxylic acids we designed, synthesized and pharmacologically evaluated seventy dicarboxylic acid esters of tropine (tropan-3a-ol) bearing substituted N-benzyl quaternizing groups. Many of the quaternary derivatives of these bistropine diesters showed high neuromuscular blocking potency, very short onset and ultrashort or short duration of action in experimental animals.
Non-RCT
Animal StudyDi- and trisubstituted benzyl bisquaternary ammonium derivatives of bis(tropan-3-ol)-diesters show high neuromuscular blocking potency, very short onset, and ultrashort or short duration of action in experimental animals.
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