Paper

Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature

Published Jul 6, 2023 · Jackson A. Roberts, V. Varma, J. Candia

NPJ Aging

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Abstract

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Observational Study

Study Snapshot

Four proteins (SMOC1, NOG, APCS, NTN1) accurately discriminate Alzheimer's disease from cognitively normal brain samples, providing insights into the disease's pathophysiology.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Unbiased proteomics and multivariable regularized regression techniques identify SMOC1, NOG, APCS, and NTN1 in an Alzheimer’s disease brain proteomic signature

References

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