Regioselective reaction of 2-bromomethyl-1,3-thiaselenole with pyridine and its derivatives is followed by rearrangement with ring expansion and the formation of a bond between a nitrogen atom and a carbon in the position 2. A set of derivatives of 2,3-dihydro-1,4-thiaselenine was obtained, substituted in the position 2 by a pyridinium residue functionalized by pharmacophoric groups.

This study demonstrates a novel reaction of 2-bromomethyl-1,3-thiaselenole with pyridine and its derivatives, leading to novel 2,3-dihydro-1,4-thiaselenine derivatives with functionalized pyridinium residues.

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Uncommon reaction of 2-bromomethyl-1,3-thiaselenole with pyridine and its derivatives

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