Unexpected stereoselective sodium acetate catalyzed multicomponent cyclization of aryl aldehydes, malononitrile and acetone into cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1 -dicarbonitriles

doi:10.1016/J.TETLET.2007.07.119

Paper

DOI: 10.1016/J.TETLET.2007.07.119

Unexpected stereoselective sodium acetate catalyzed multicomponent cyclization of aryl aldehydes, malononitrile and acetone into cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1 -dicarbonitriles

Published Sep 17, 2007 · M. Elinson, A. N. Vereshchagin, Sergey K. Feducovich

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Abstract

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This new multicomponent reaction, catalyzed by sodium acetate, produces cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1-dicarbonitriles in 30-60% yields.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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One-pot five-component high diastereoselective synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitriles, dialkyl malonates and ammonium acetate

This novel five-component diastereoselective synthesis of polysubstituted 2-piperidinones from aromatic aldehydes, nitriles, dialkyl malonates, and ammonium acetate provides convenient access to alkyl (3 SR,4

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Highly diastereoselective four-component synthesis of polysubstituted 2-piperidinones with three and four stereogenic centers

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Ultrasensitive Optical Chemosensor for Cu(II) Detection

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This method enables the stereoselective synthesis of (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates with 55-87% yields, using benzylid

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